天津市自然科学一等奖（2/3）

主持在研项目：

--面向神经疾病的高通量异构组学数据集成分析的关键方法研究，No.61973174 国家自然科学基金面上项目（负责人）

--智能计算平台子课题，NO.2018YFB0204304 国家重点研发计划项目，参与人

--国家社科基金重大项目：大数据背景下医患关系的分析与政策研究：18ZDA087（子课题负责人）

--面向功能与注释的蛋白质分类与识别的智能方法研究，21JCZDJC00140天津市自然基金重点项目（负责人）

已结题项目：

--国家自然科学基金项目海外及港澳学者合作研究基金-碳水化合物活性酶家族分类与深度注释的生物信息工具研究和开发:31728013(中方负责人)

--天津市应用基础与前沿技术研究计划项目: 基于大肠埃希菌的染色体超螺旋折叠边界研究:15JCYBJC18900（负责人）

--国家自然科学基金项目: 基于本体的计算机病毒自适应建模方法研究 项目批准号:61004086        (负责人)

--教育部博士点基金: 复杂网络下基于语义建模的智能病毒防御技术研究,课题号200800551024(负责人)

--天津市自然科学基金: 基于保守混沌系统的密码新理论与新方法研究,项目号:07JCYBJC14700,   (负责人)

研究室开发重要软件、数据库、服务器最新地址：

GDASC：https://bioinfo.nankai.edu.cn/

DASC:  https://github.com/zhanglabNKU/DASC

dbCAN2: http://bcb.unl.edu/dbCAN2/

dbCAN-seq: http://bcb.unl.edu/dbCAN_seq/index.php

eCAMI: https://github.com/zhanglabNKU/eCAMI

pHMM-tree: http://bcb.unl.edu/pHMM-Tree/source/index.php

APIN: https://github.com/zhanglabNKU/APIN

近期论文：

(1) Qingqing Zhao; Han Zhang*; Mengyao He; Wei Li; Chuanze Kang; Mingjing Han; Graph pooling via Dual-view Multi-level Infomax, Knowledge-Based Systems, 2022, 260(2023)：1-15.

(2) Mingjing Han; Han Zhang*; Multiple Kernel Learning for Label Relation and Class Imbalance in Multi-label Learning, Information Sciences, 2022, 613(2022)：344-356.

(3) Wanwan Huang; Han Zhang*; Zeyuan Li; Yanbin Yin; Mutual Information Estimation-Based Disentangled Representation Network for Medical Image Fusion, 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 最佳学生论文奖，Best Student Paper.

(4) Mengyao He; Qingqing Zhao; Han Zhang*，et al. Graph Representation Learning via Redundancy Reduction. Neurocomputing, accepted.

(5) Guan Hou#, Yuhao Jian#, Qingqing Zhao, Quan Xiongwen and Han Zhang*. Language Model based on Deep Learning Network for Biomedical Named Entity Recognition. The 21th Asia Pacific Bioinformatics Conference(APBC)CCF C类会议, accepted.

主要论文：

About Data mining and artificial intelligence:

1.Wei Li, Han Zhang*, Minghe Li, Mingjing Han and Yanbin Yin, MGEGFP: a multi-view graph embedding method for gene function prediction based on adaptive estimation with GCN, Briefings in Bioinformatics, 2022, doi: 10.1093/bib/bbac333,SCI一区,影响因子13.994.

2.Wanwan Huang, Han Zhang*, Xiongwen Quan, Jia Wang. A Two-level Dynamic Adaptive Network for Medical Image Fusion, IEEE Transactions on Instrumentation & Measurement, 2022, 10.1109/TIM.2022.3169546.

3.Xiao Wang, Jia Wang, Han Zhang*, Shenwei Huang, Yanbin Yin. HDMC: a novel deep learning based framework for removing batch effects in single-cell RNA-seq data. Bioinformatics, 2021，doi.org/10.1093/bioinformatics/btab821，SCI一区

4.Chuanze Kang, Han Zhang*, Zhuo Liu, Shenwei Huang, Yanbin Yin. LR-GNN: a graph neural network based on link representation for predicting molecular associations. Briefings in Bioinformatics, 2021, doi.org/10.1093/bib/bbab513，SCI一区，影响因子13.994

5.Chen Jin, Jianzhao Gao, Zhuangwei Shi, Han Zhang*. Attcry: attention-based neural network model for protein crystallization prediction. Neurocomputing, 2021, 463, 265-274.

6.Jia Wang, Xiao Wang, Han Zhang*. Domain-aware Multi-modality Fusion Network for Generalized Zero-shot Learning. Neurocomputing, 2022, doi.10.1016/j.neucom.2022.02.056.

7.Wei Li, Han Zhang*, Qingqing Zhao, Jian Liu, and Yanbin Yin, Adversarial Dual-Channel Variational Graph Autoencoder for Synthetic Lethality Prediction in Human Cancers. 2021 BIBM,regular paper. CCF B类会议

8.Chen Jin, Zhuangwei Shi, Han Zhang*, and Yanbin Yin, Predicting lncRNA protein interactions based on graph autoencoders and collaborative training. 2021 BIBM,regular paper. CCF B类会议

9. Wei Li, Qingqing Zhao, Han Zhang*, Xiongwen Quan, Jing Xu, and Yanbin Yin,Bayesian Multi-scale Convolutional Neural Network for Motif Occupancy Identification, 2020 BIBM,regular paper.CCF B类会议

10. Le Huang, Bowen Yang, Haidong Yi, Amina Asif, Jiawei Wang, Trevor Lithgow, Han Zhang, Fayyaz ul Amir Afsar Minhas, Yanbin Yin*. AcrDB: a database of anti-CRISPR operons in prokaryotes and viruses. Nucleic Acids Research, doi.org/10.1093/nar/gkaa857.2021 SCI一区.

11. Shi, Zhuangwei; Zhang, Han*; Jin, Chen, A representation learning model based on variational inference and graph autoencoder for predicting lncRNA-disease associations, BMC Bioinformatics,2021, 22(1): 589:1-589:11. SCI，影响因子2.213

12.Xiao Wang, Haidong Yi, Jia Wang, Zhandong Liu, Yanbin Yin, Han Zhang*. GDASC: A GPU parallel based web server for detecting hidden batch factors.Bioinformatics,doi.org/10.1093/bioinformatics/btaa427. 2020 SCI一区

13.Jing Xu, Han Zhang*, Jinfang Zheng, Philippe Dovoedo, Yanbin Yin. eCAMI: simultaneous classification and motif identification for enzyme annotation.Bioinformatics, Volume 36, Issue 7, 1 April 2020, Pages 2068–2075,SCI一区

14.Haidong, Y. , Le, H. , Bowen, Y. , Javi, G. , Han, Z. , & Yanbin, Y. *.Acrfinder: genome mining anti-crispr operons in prokaryotes and their viruses. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa351 2020. SCI一区，影响因子19.160

15. Xin Su, Jing Xu, Yanbin Yin, Xiongwen Quan, Han Zhang*.Antimicrobial Peptide Identification Using Multi-scale Convolutional Network. BMC Bioinformatics,(2019) 20:730,doi.org/10.1186/s12859-019-3327-y SCI

16. Wei Li , Yanbin Yin , Xiongwen Quan, Han Zhang*. Gene Expression Value Prediction Based on XGBoost Algorithm. Frontiers in Genetics, 2019,12，SCI

17.Han Zhang, Xueting Huo, Xia Guo, Xin Su, Xiongwen Quan, and Chen Jin, A Disease-related Gene Mining Method Based On Weakly Supervised Learning Model，2018 BIBM, regular paper，CCF B类会议.（推荐至BMC Bioinformatics, 2019, 20，SCI）

18. Han Zhang, Tanner Yohe, Le Huang, Sarah Entwistle, Peizhi Wu,Zhenglu Yang, Peter Busk, Ying Xu, Yanbin Yin. dbCAN2: a meta server for automated carbohydrate-active enzyme annotation. Nucleic Acids Research(2018 Web Server-Issue), https://doi.org/10.1093/nar/gky418.SCI一区，影响因子19.160(新网址http://bcb.unl.edu/dbCAN2/ ) 2019 ESI 0.1% 热点论文，高被引论文（SCI引用843次）

19.Haidong Yi, ayush.raman, Han Zhang*, Genevera Allen,Zhandong Liu*. Detecting hidden batch factors through data adaptive adjustment for biological effects. Bioinformatics ,2017,  (通讯作者),doi: 10.1093/bioinformatics/btx635 ,SCI一区，2017影响因子7.307

20.Xue Jiang; Han Zhang; Feng Duan; Xiongwen Quan.Identify Huntington's disease associated genes based on restricted Boltzmann machine with RNA-seq data. BMC Bioinformatics, December 2017, 18:447.

21.Huang, Le; Zhang, Han*; Wu, Peizhi; Entwistle, Sarah ; Li, Xueqiong; Yohe, Tanner ; Yi, Haidong; Yang, Zhenglu; Yin, Yanbin*. dbCAN-seq: a database of carbohydrate-active enzyme (CAZyme) sequence and annotation. Nucleic Acids Research,doi:10.1093/nar/gkx894 , (通讯作者)SCI一区，影响因子19.160 （新网址 http://bcb.unl.edu/dbCAN_seq/index.php）（SCI引用129次）

22.Luyang Huo,Han Zhang*,Xueting Huo,Xueqiong Li,Yanbin Yin*. pHMM-tree: Phylogeny of Profile Hidden Markov Models .Bioinformatics ,2017,  (通讯作者).doi: 10.1093/bioinformatics/btw779,SCI一区，2017影响因子7.307

23.Yanbin Yin#, Zhang H.#, Olman, V., Xu, Y. (2010) Genomic arrangement of bacterial operons is constrained by biological pathways encoded in the genome. Proc Natl Acad Sci USA 107(14): 6310-6315 PubMed (*equal contribution),《美国国家科学院院刊》,PNAS,并列第一作者, PubMed, http://www.ncbi.nlm.nih.gov/pubmed/20308592,SCI一区,2010年影响因子9.771，检索号000276374400035

24.Zhang, H.#, Yanbin Yin#, Olman, V. and Xu, Y*. (2012) Genomic arrangement of regulons in bacterial genomes. PLoS ONE, 10.1371/journal.pone.0029496 .

25.Xizeng Mao, Han Zhang, Yanbin Yin, and Ying Xu*. The percentage of bacterial genes on leading versus lagging strands is influenced by multiple balancing forces. Nucleic Acids Research, 2012, 1–9 doi:10.1093/nar/gks605，June 26, 2012, SCI一区，影响因子19.160

26.Qin Ma, Yanbin Yin, Mark A. Schell, Han Zhang, Guojun Li,and Ying Xu*,Computational analyses of transcriptomic data reveal the dynamic organization of the Escherichia coli chromosome under different conditions,Nucleic Acids Research ,2013, 1–10 doi:10.1093/nar/gkt261,SCI一区，影响因子19.160

27.Shuo Gao, Li Gao, Xiongwen Quan*, Han Zhang, Hang Bai, Chuanze Kang.Automatic arteriosclerotic retinopathy grading using four-channel with image merging. Computer Methods and Programs in Biomedicine, 2021, 208: 106274, https://doi.org/10.1016/j.cmpb.2021.106274,SCI二区

28.Hang Bai, Li Gao, Xiongwen Quan*, Han Zhang, Shuo Gao, Chuanze Kang, Jiaqiang Qi. OTNet: A CNN Method Based on Hierarchical Attention Maps for Grading Arteriosclerosis of Fundus Images with Small Samples. Interdisciplinary Sciences: Computational Life Sciences, 2021, https://doi.org/10.1007/s12539-021-00479-8，SCI二区

29.Xingyuan Ou; Li Gao; Xiongwen Quan*;Han Zhang; Jinglong Yang; Wei Li. BFENet: A Two-Stream Interaction CNN Method for Multi-Label Ophthalmic Diseases Classification with Bilateral Fundus Images, Computer Methods and Programs in Biomedicine,2022，SCI二区

About computer information security

1.付垒朋, 张瀚*, 霍路阳.基于多类特征的智能恶意脚本检测算法[J] 《模式识别与人工智能》, 2015,28卷,12期(通讯作者) .

2.张涛, 张瀚*, 付垒朋.基于模糊模式与决策树融合的脚本病毒检测算法[J] 《电子与信息学报》, 2014,V36(1): 108-113(通讯作者) ,EI.

3.Jicai HUANG, Han ZHANG; Bifurcations of periodic orbits in Three-well Duffing system with a phase shift. Journal of Systems Science and Complexity(2011) 24: 519–531,(SCI三区)

4.Qing-Hua Zhang, Han Zhang, and Zhao-Hui Li, One-way Hash Function Construction Based on Conservative Chaotic Systems, Journal of Information Assurance and Security ,5 (2010) 171-178

5.Han Zhang, Jicai Huang, Zhaohui Li ,New method of digital image scrambling based on binary tree generated by chaotic sequences,MIPPR 2007 , Processing of SPIE, Vol.6790, 67905D, 2007(EI: 081911239767)

6.张瀚，王秀峰，李朝晖,刘大海，一种基于时空混沌的Hash函数构造，《物理学报》, Vol.54（9）:4006－4011，2005.9 (EI :05389375776,SCI: 960DD).

7.张瀚，王秀峰，李朝晖,刘大海，一种基于混沌系统及Henon映射的快速图像加密算法,《计算机研究与发展》, Vol.42（12）：2137－2142，2005.12. (EI:06029638018)

8.Zhang Han, Wang Xiu Feng, Li Zhao Hui, et al.A new image encryption algorithm based on chaos system.Proceedings. 2003 IEEE International Conference on Robotics, Intelligent Systems and Signal Processing (IEEE Cat. No.03EX707) 778-782 vol.2 2003

9.Li Zhao-hui,Wang Xiu-feng,Zhang Han, A Research on Gray Level Mixing Function in Two-Dimensional Chaotic Map Image Encryption, Proceedings of Second International Conference on Image and Graphics , Wei Sui, P93_102, 16-18 August 2002, Hefei, P.R.China. ( EI :02527290071 )

10.Chao Zuo, Cong Xiong, Han Zhang, Chang Fang, Graph coloring based channel assignment framework for rural wireless mesh networks,Journal of Electronics (China) September 2013 .

授权专利：一种基于本体的计算机病毒分析系统及其特征提取方法 证书号2025191